26 Renal Tumors

_..

• 1st 3 kidney cancer, RCC most common

• last 3 bladder cancer, transitional most common

RCC

_..

• cigarette and obesity very important

_..

• few pts have classic triad, most just have hematuria

_..

• glycogen/lipids do not stain very well

• N: normal

• circle: yellow mass

• F: fat

_..

_..

_..

• IL 2 part of inflammatory response, like giving flu to someone

• Plush cancer crab in kidney machine: interferon alpha treats renal cell carcinoma

Wilm's

[_](Wilm's tumor epidemiology, type of cell, classic case)..

• HTN in children very rare

• average age 3

• tumor in child kidney, think Wilm's

• composed of blastema: primitive kidney tissue

• large unilateral flank mass

[_](Wilm's histology and gross)..

[_](Wilm's inheritance and mutation, association)..

• very rare

• neonatal hypoglycemia

• large tongue

Angiomyolipoma

_..

• angio: blood vessel; myo: smooth muscle; lipoma: fat

• cortical tuber: growth or bulge

• very important: leaf-like patches of skin, pale skin in shape of leaf

• Lack of migration

• Neocortical tubers: very hard and white. Glia and neurons jumbled up

• Nodules around ventricles

• Brain tumors SEGA

• top: discolored areas

• SEGA: blocking fluid in ventricles = hydrocephalus. Tube to drain extra fluid

• don't worry about histology.

• Big mass in child

• Looks like fat in middle of kidney

Transitional Cell Carcinoma

_..

• flat pathway: high grade flat tumor then invades. Early p53 mutation

• papillary: low grade papillary tumor that progress to high grade and then invade. Not association with p53

_..

• smoker with hematuria: think bladder cancer

• phenacetin: analgesic

• any industrial job

• Cancer crab belt buckle: cyclophosphamide increases risk of bladder cancer (high grade transitional cell carcinoma)

_..

• cast: glomerular source of bleeding

• platinum used for transitional

Squamous Cell

_..

Adenocarcinoma

_..