06 Imprinting

• gene expression not structure

• different expression depending on whether from mother or father

• normally both copies expressed

• imprinting: one of the copy not expressed

Pathology

Prader-Willi

• P for paternal and prader

• maternal normally not expressed

• loos of paternal = no functioning gene

• angelman severe intellectual

Angelman

• meiotic nondisjunction rarer in males