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On this page
  • Pressure Volume Curve
  • PV Curve
  • Isovolumetric contraction
  • Systolic ejection
  • Isovolumetric Relaxation
  • Ventricular Filling
  • Valves
  • Preload Increases
  • Preload Decreases
  • Afterload Increases
  • Contractility Increases
  • Decreased Contractility
  • Compliance Changes
  • Jugular Venous Tracing
  • A Wave
  • Absent a wave
  • Large/giant a wave
  • Cannon a wave
  • V wave
  • Large, giant V wave
  • C wave
  • X Descent
  • Absent x descent
  • Prominent x descent
  • Y Descent
  • Absent y
  • Slow y
  • Rapid y
  • Tricuspid valve opens
  • Tricuspid valve closes
  • Cardiac Cycle
  • Atrial Systole
  • S1
  • Isovolumetric Ventricular Contraction
  • Rapid Ventricular Ejection
  • Reduced Ventricular Ejection
  • S2
  • Isovolumetric Ventricular Relaxation
  • Dicrotic Wave
  • Rapid Ventricular Filling
  • S3
  • S4

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  1. 01 Step 1
  2. Cardiology

04 Cardiac Cycle

Previous03 Congenital Heart DiseaseNext06 PV Loop

Last updated 5 years ago

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Pressure Volume Curve

PV Curve

..

Isovolumetric contraction

.,At point 3, the cycle is at end diastole with the mitral valve closed; LV has been filled by the EDV. The ventricles begin contraction when the mitral valve closes and before the aortic valve opens (point 5), the period of highest O2 consumption

Systolic ejection

.,At point 5, pressure in ventricle rises high enough to push open aortic valve and the total stroke volume is ejected into the aorta. The ventricle volume decreases, but the ventricular pressure continues to increase until near the very end of this phase. At point 7 , the pressure drop causes the aortic valve to close. The width of the pressure-volume loop is measured graphically to represent the stroke volume. The volume remaining in the LV at point 7 is end systolic volume.

Isovolumetric Relaxation

.,After point 7, the ventricle begins to relax. Since all the valves are closed again, the ventricular volume is constant (isovolumetric) in this phase

Ventricular Filling

.,At point 1, the mitral valve opens and the filling of the ventricles begins. Initially, a rapid filling period begins which is followed by a reduced filling

Valves

[](Valves on PV Curve <img src='d839YQG.jpg' alt='' /)..

  • 3: mitral valve closes

  • 5: aortic valve opens

  • 7: aortic valve closes

  • 1: mitral valve opens

Preload Increases

Preload Decreases

Afterload Increases

  • Requires the ventricle to pump against a higher pressure = higher pressure overall

  • At end of systole, same pressure leaves more volume in the ventricles = increased ESV = decreasing stroke volume..

Contractility Increases

Decreased Contractility

Compliance Changes

When Value High

SV

EDV

ESV

Preload

up

up

same

Compliance

up

up

same

Contractility

up

same

down

Afterload

down

same

up

Jugular Venous Tracing

  • Jugular vein

  • Right atrium, left atrium

  • Pulmonary vein..

  • c: tricuspid valve/mitral valve close. S1 sound

  • v: atrium relax, blood to RV..

A Wave

a wave = Atrial contraction

Absent a wave

Large/giant a wave

  • Tricuspid stenosis

  • Right ventricular hypertrophy

  • Pulmonic stenosis

  • Pulmonary hypertension

  • Right atrial myxoma

  • RHF.,

Cannon a wave

  • Vent Tach

  • 3rd degree (complete) heart block

  • PAC/PVC.,

V wave

v wave = Venous filling

Large, giant V wave

C wave

c wave = triCuspid valve

X Descent

X descent = atrial relaXation

Absent x descent

Prominent x descent

  • Constrictive pericarditis (also has a prominent “y” descent)

  • Cardiac tamponade (absent “y” descent).,

Prominent x descent due to high JVP

Y Descent

Absent y

In cardiac tamponade, right ventricular filling is impaired throughout diastole, and therefore the y-descent (which represents the fall in right atrial pressure immediately after tricuspid valve opening as blood rushes into the right ventricle) is blunted (less steeply downsloping).

In Tamponade, active pressure is being exerted on the heart throughout the cardiac cycle. The pericardial pressure exceeds the diastolic pressure, leading to decreased filling pressure gradient. This results in a blunted or absent Y descent.

Slow y

Rapid y

  • Constrictive pericarditis

  • Severe right heart failure

  • Tricuspid regurgitation (The large CV wave sets the stage for a large “y” descent.).,

In pericardial constriction, the earliest phase of diastolic right ventricular filling is not impaired and the y-descent is not blunted -- in fact, because it is descending from a higher-than-normal right atrial pressure, the y-descent may be accentuated, commonly called a "rapid y-descent".

In Constrictive Pericarditis, the pericardium is rigid and can't move inwards or outwards properly. During the cardiac cycle, the ventricle is constricted after its systole but pericardium has not moved with it. Therefore there is lots of room in between and there is minimal pressure at the start of diastole. This leads to rapid ventricular filling as no resistance is offered to the expanding ventricle. This results in a prominent Y descent.

Tricuspid valve opens

Tricuspid valve closes

Happens during S1

Cardiac Cycle

  1. Atrium contract, pump blood into ventricle

  2. Mitral valve and tricuspid closes

  3. Isovolumetric ventricular contraction

  4. Aortic and pulmonic valve opens

  5. Blood flows from ventricle to aorta and pulmonary artery

  6. Aortic valve closes

  7. isovolumetric relaxation

  8. Mitral valve opens, back to #1..

Atrial Systole

JVP shows a wave:

S1

EKG: S1 is QRS

JVP shows c wave. c wave = triCuspid valve closing and bulging into RA

Isovolumetric Ventricular Contraction

JVP: c wave from triCuspid valve bulging into RA

PV curve goes from 3 to 5

Rapid Ventricular Ejection

Reduced Ventricular Ejection

Follows rapid ventricular ejection and results from decreased ventricular volume. This follows the length-tension relationship described by the Frank-Starling equation, where contraction strength is directly related to the load; therefore, a decreased volume would translate into a decreased load, which means less contraction strength and reduced ventricular ejection.

  • X descent = atrial relaXation

  • V wave = Venous filling

PV curve goes from 5 to 7

S2

V wave = Venous filling

Isovolumetric Ventricular Relaxation

V wave = Venous filling. Right after T wave on EKG

PV curve goes from 7 to 1

Dicrotic Wave

Rapid Ventricular Filling

y = atrium emptYing

PV curve goes from 1 to 3

S3

  • Demographics: young patients <30, pregnant women

  • Vigorous LV relaxation lowers pressure rapidly, resulting in rapid LV filling

  • Normal LA pressure..

  • High LA pressure, leading to rapid early filling of LV

  • Usually association with high LVEDP (dilated ventricle)..

S4

  • Long standing HTN

  • Hypertrophic cardiomyopathy

  • Diastolic HF.,

..

Point 3 to 5

Point 5 to 7.

Point 7 to 1.

Point 1 to 3.

Leads to an increase in ventricular end-diastolic volume and results from increased venous return. This, in turn, results in an increase in stroke volume and ejection fraction based on the Frank-Starling relationship. Since increased preload causes increased stroke volume, this results in an increased width of the pressure-volume loop..

Decreased width..

The ventricle is able to develop greater tension than usual during systole, causing an increase in stroke volume..

..

Stiffer ventricle: higher pressure at lower volume. This results in a decrease in end-systolic volume..

Measures pressure in the:

Increase in right atrial pressure during atrial contraction (i.e atrial systole).,

Characteristic of atrial fibrillation due to a lack of coordinated atrial contraction.,

Indicate the right atrium is contracting against increased resistance to right ventricular filling. May be seen with:

Are caused by the right atrium contracting against a closed tricuspid valve, which most commonly occurs during junctional arrhythmias

Increase in right atrial pressure during late ventricular systole due to right atrial filling against a closed tricuspid valve. Usually corresponds with (or occurs just after) the T wave on EKG.,

aka CV fusion.,

Can occur due to tricuspid or mitral regurgitation.,

Increase in right atrial pressure during right ventricular isovolumic systole (contraction); due to bulging of the tricuspid valve into the right atrium.,

Is the decrease in jugular venous pressure due to movement of blood from the venous system to the right atrium. It is caused by atrial relaxation and the downward displacement of the closed tricuspid valve during right ventricular systole.,

Occurs in tricuspid regurgitation. Backflow of blood into the right atrium during systole prevents relaxation of right atrial pressure. (may see a positive wave).,

Occurs in:

Decrease in right atrial pressure following the peak of the “v” wave; due to tricuspid valve opening and right atrium emptYing.,

Cardiac tamponade (The right atrium is unable to relax following the "v" wave due to the presence of fluid around the heart).,

Tricuspid stenosis is a common cause on JVP.,

Occurs in:

From v wave to c wave.,

From c to v wave.,

The process of cardiac filling and ejection, and is often visualized with electrocardiography or jugular venous pressure readings..

Cardiac cycle overview process:

The activation of the atria, pumping atrial blood into the ventricles. Also known as atrial kick. Happens before mitral valve closes..

The sound of the atrioventricular (tricuspid and mitral) valves closing; it occurs at the beginning of isovolumetric ventricular contraction and beginning of QRS.,

The ventricles contract after mitral valve closes and before the aortic and pulmonic valves open.,

Isovolumetric contraction..

The period of ventricular contraction after the aortic and pulmonic valves have opened (pushed open by pressure) and before middle point of ejection cycle, when the ventricles are ejecting blood into the pulmonic and systemic circulations.,

Is the sound of the aortic and pulmonic valves closing.,

Normally, the aortic valve closes before the pulmonic valve. "Splitting” of the second heart sound can occur during inspiration when negative intrathoracic pressure increases venous return, ultimately delaying closure of the pulmonic valve..

The period between the aortic valve closing and the mitral valve opening.,

The trough is where the aortic valve closed, and the following "bump" in pressure results from aortic pressure recoil against a closed aortic valve..

Happens when the atrial pressure becomes slightly greater than the ventricular pressure. It starts when the mitral and tricuspid valves open.,

Results from blood sloshing against the ventricular walls during the middle third of diastole.,

Physiologic S3, aka suckers:

Pathologic S3, aka pushers:

Louder when patient lies on left side and with exhalation due to heart closer to chest wall.,

Sounds like Ken-tu-cky.,

Is a low frequency diastolic sound that occurs during the late diastolic filling phase (the atrial kick). It results from an atrial kick filling a ventricle with decreased compliance, often seen in left ventricular hypertrophy. (Blood hitting stiff wall).,

Usually caused by stiff left ventricle from:

Cannot occur in Afib because there is no atrial kick.,

It is sometimes heard in the elderly due to a stiff ventricle.,

Sounds like Ten-nes-see.,

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