21 Amyloidosis

• clump of proteins in extracellular space of tissues

• lots and lots of different amyloid proteins that can accumulate

• common features of all amyloid

• biopsy similar to other proteins, use stain

• also common feature

Systemic

• age related: senile

Transthyretin

• transports thyroid: transthyretin

• ATTR: name for amyloidosis with transthyretin

• cardiac form of amyloidosis

• takes years to build up

AL

• primary amyloidosis

AA

• secondary amyloidosis: occurs secondarily to inflammation

• Acute phase reactants: levels elevated in inflammation

Familial Mediterranean Fever

• in mediterranean countries

• serosal surfaces, abdomen, mimic appendictis

• neutrophil disorder

Dialysis

Symptoms by organs

• brain: Alzheimer

• pancreas: type 2 diabetes, amylin

• thyroid: medullary carcinoma, calcitonin deposition

• common with AL and age related