My Wiki
  • Introduction
  • 01 Step 1
    • Antimicrobials
      • 01 Cell Wall And Membrane
      • 02 Protein Synthesis
      • 03 Others
      • 04 Antimicrobials
    • Behavior Science
      • Development
      • Public Health Copy
      • Public Health
    • Biochemistry
      • 01 DNA Structure
      • 02 Purine
      • 03 Pyrimidine
      • 04 Glucose
      • 05 Glycolysis
      • 06 Gluconeogenesis
      • 07 Glycogen
      • 08 HMP Shunt
      • 09 Fructose And Galactose
      • 10 Pyruvate Dehydrogenase
      • 11 TCA
      • 12 ETC
      • 13 FA
      • 14 Ketones
      • 15 Ethanol
      • 17 Inborn Errors
      • Ammonia
      • B Vitamins
      • Lysosomal Storage Diseases
      • Other Vitamins
    • Cardiology
      • 01 Cardiac Anatomy
      • 01 Cardiac Embryology
      • 02 Heart Physiology
      • 03 Congenital Heart Disease
      • 04 Cardiac Cycle
      • 06 PV Loop
      • 07 Wiggers And Venous
      • 09 Starling
      • 10 Cardiac Ischemia
      • 11 Stable Angina
      • 14 EKG Basics
      • 15 EKG Others
      • 15 High Yield EKG
      • 16 Cardiac AP
      • 17 BBB
      • 21 Antiarrhythmics
      • 22 Heart Murmurs
      • 23 Heart Sounds
      • 24 HF Basics
      • 25 Systolic Diastolic HF
      • 26 Restrictive Cardiomyopathy
      • 27 Acute HF
      • 28 Chronic HF
      • 30 Shunts
      • 31 Congenital Heart Disease
      • 32 Hypertension
      • 33 Antihypertensives
      • 34 Valvular Disease
      • 35 Shock
      • 36 Pericardial Disease
      • 37 Aortic Dissection
      • 38 Cardiac Tumors
      • 39 Hypertrophic Cardiomyopathy
      • 40 Endocarditis
      • Chest Pain
    • Cell
      • 01 DNA
      • 02 DNA Mutation
      • 03 DNA Repair
      • 04 Transcription
      • 05 Translation
      • 06 PCR
      • Cell Cycle
      • Cell Structure
      • CT
      • Cytoskeleton
    • Endocrinology
      • 01 Thyroid
      • 02 Thyroid Disorders
      • 03 Adrenal Gland
      • 04 Adrenal Disorders
      • 05 CAH
      • 06 Pituitary Anatomy
      • 07 Pituitary Secretions
      • 08 Pituitary Pathology
      • 10 Endocrine Pancreas
      • 11 Diabetes
      • 12 Diabetes Treatment
      • 13 Insulin
      • 14 Parathyroid
      • 15 MEN
    • Genetics
      • 01 Genetic Principles
      • 02 Gene Mapping
      • 03 Meiosis
      • 04 Hardy
      • 05 Pedigree
      • 06 Imprinting
      • 07 Down
      • 08 Trisomy
      • 09 AD
      • Deletion
      • Trinucleotide Disorders
    • GI
      • 01 Embryology
      • 02 GI Anatomy
      • 03 GI Blood
      • 04 GI Tract
      • 05 Liver Gallbladder Pancreas
      • 06 Salivary
      • 07 Hernia
      • 08 Bile
      • 09 Bilirubin
      • 10 GI Secretion
      • 11 GI Hormones
      • 12 Exocrine Pancreas
      • 13 Esophageal Disorders
      • 14 Liver Disease
      • 15 Cirrhosis
      • 16 Liver Tumors
      • [17 Wilson S](01 Step 1/GI/17 Wilson's.md)
      • 18 Gallstones
      • 19 Biliary Disorders
      • 20 Gastric
      • 21 Malabsorption
      • 22 Acute Pancreatitis
      • 23 Chronic Pancreatitis
      • 24 Intestinal Disorders
      • 25 IBD
      • 26 Colon Cancer
    • Heme
      • 01 Coagulation
      • 02 Platelets
      • 03 Hypercoagulable States
      • 04 Coagulopathies
      • 05 Platelet Disorders
      • 06 Antiplatelet
      • 08 Hemolysis Basics
      • 09 Extrinsic Hemolysis
      • 10 Intrinsic Hemolysis
      • 11 Microcytic Anemia
      • 12 Thalassemia
      • 13 Sickle Cell
      • 14 Other Anemias
      • 15 Blood Groups
      • 16 Acute Leukemia
      • 17 Chronic Leukemia
      • 18 Hodgkin Lymphoma
      • 19 Nonhodgkin Lymphoma
      • 20 Plasma Cell Disorders
      • 21 Amyloidosis
      • 22 Myeloproliferative
      • 23 Porphyrias
    • Immunology
      • 01 Innate Immunity
      • 02 T Cells
      • 03 B Cells
      • 04 Complement
      • 05 Spleen
      • Antibodies
      • Glucocorticoids
      • Hypersensitivity
      • Immune Deficiencies
      • Immunosuppressants
      • Lupus
      • Rheumatoid Arthritis
      • Scleroderma
      • Sjogren
      • Transplants
      • Vasculitis
    • Infectious Disease
      • 01 Bacteria
      • 02 Bacteria Culture
      • 03 Bacteria Virulence
      • 04 Virus Structure
      • 05 Bacterial Genetics
      • Malaria
      • Virus Sturcture
    • Microbes
      • 01 Gm Positive Cocci
      • 02 Gm Positive Bacilli
      • 03 Gm Negative Cocci
      • 04 Gm Negative Enteric Bacilli
      • 05 Gm Negative Respiratory Bacilli
      • 06 Gm Negative Zoonotic Bacilli
      • 07 Mycobacterium
      • 08 Spirochetes
      • 09 Gm Indeterminate
      • 10 Parasites
      • 11 Virus
      • Fungi
      • Herpes
      • Sketchy
      • Strep
    • MSK
      • 01 Bone Disorders
      • 01 Knee
      • 02 Shoulder
      • 03 Brachial
      • 04 Wrist
      • 05 Hand
      • 06 Lumbosacral
      • 07 Hip
      • 08 Bone Biology
      • 09 Skeletal Muscles
      • Dermatomes
    • Neurology
      • 01 CNS Cells
      • 02 Wallerian Degeneration
      • 03 BBB
      • 04 Neurotransmitters
      • 06 Cerebral Cortex
      • 07 Spinal Cord
      • 08 Spinal Cord Syndromes
      • 09 Brainstem
      • 10 Cranial Nerves
      • 11 Auditory System
      • 12 Vestibular System
      • 13 Thalamus
      • 14 Cerebellum
      • 15 Basal Ganglia
      • 16 Ventricles And Sinuses
      • 17 Cerebral And Lacunar Strokes
      • 18 Vertebrobasilar Stroke
      • 19 CNS Aneurysm
      • 20 Intracranial Bleeding
      • 21 Management Of Stroke
      • 25 Pupil
      • 26 Lens
      • 27 Retina
      • 30 Gaze Palsies
      • 31 Structural Eye Disorders
      • 32 Glaucoma
      • 36 Meningitis
      • 37 Seizures
      • 39 Dementia And Delirium
      • 40 Demyelinating Diseases
      • 41 Headaches
      • 42 Brain Tumors
      • 43 Movement Disorders
      • 44 CNS Infections
    • Pharm
      • 01 Autonomics
      • 02 Cardiorenal
      • 03 Blood
      • 04 Smooth Muscles
      • 05 GI
      • Analgesics
      • Antineoplastics
      • Cholinometics
      • CYP 450
      • Parkinson
      • Psych
      • Sedatives
    • Pharmacology
      • 01 Enzymes
      • 02 Inhibitors
      • 03 Dose
      • 04 Drug Elimination
      • 05 Pharmacokinetics
    • Pulmonary
      • 01 Pulmonary Anatomy
      • 02 Pulmonary Physiology
      • 03 Hemoglobin
      • 04 Pulmonary Circulation
      • 05 Hypoxia
      • 06 Ventilation
      • 07 CO 2
      • 08 Pulmonary Exam
      • 09 PFT
      • 10 Obstructive
      • 11 Restrictive
      • 12 COPD Treatment
      • 13 Pneumonia
      • 14 Pleural Disease
      • 15 Lung Cancer
      • 16 Sleep Apnea
      • 17 Cystic Fibrosis
      • 18 TB
      • 19 Sarcoidosis
      • 20 PE
      • 21 Xray
    • Renal
      • 01 Renal Embryology
      • 02 Renal Anatomy
      • 03 Renal Physiology 1
      • 04 Renal Physiology II
      • 05 Nephron Physiology
      • 06 Renal Endocrine
      • 07 Acid Excretion
      • 08 Acid Base Principles
      • 09 Respiratory Disorders
      • 10 Metabolic Disorders
      • 11 RTA
      • 12 Metabolic Acidosis
      • 13 Electrolytes
      • 14 Na And Water
      • 15 Na Disorders
      • 16 Glomerulonephritis Principles
      • 17 Nephritic Syndrome
      • 18 Nephrotic Syndrome
      • 19 MPGN
      • 20 Tubulointerstitial Disease
      • 21 Renal Failure
      • 22 UTI
      • 23 Cystic Kidney
      • 24 Diuretics
      • 25 Renal Stones
      • 26 Renal Tumors
      • 27 Rhabdomyolysis
      • 28 Pathogenesis
    • Reproductive
      • Breast Disorders
      • Breast
      • Candida Albicans
      • Chlamydia Trachomatis
      • Disorders Of Sexual Differentiation
      • Female Pathology
      • Female Reproductive Embryology And Anatomy
      • Gardnerella Vaginalis
      • HPV
      • Male Anatomy
      • Male Pathology
      • Neoplastic Ovarian Pathology
      • Ovarian Pathology
      • Pharyngeal Arches
      • Preeclampsia
      • Testicular Pathology
      • Treponema Pallidu
      • Trichomonas Vaginalis
    • Uworld
      • Uworld Notes 2
      • Uworld Notes 3
      • Uworld Notes
  • 02 Step 2
    • Family
      • A Complicated Pregnancy
      • A Healthy Pregnancy
      • AAFP Questions
      • Derm
      • Family Planning
      • Labor
      • Postpartum Complications
      • Reproductive Endocrinology
    • Internal
      • 01 Cardiology
      • 01 EKG
      • 02 Pulmonary
      • 02 Pulmonary 2
      • 03 Pediatric
      • 04 Dermatology
      • 05 Endocrine
      • 06 GI
      • 07 Heme
      • 07 Heme 2
      • 08 Infectious Disease
      • 09 Fluid
      • 09 Nephrology
      • 09 Nephrology 2
      • 10 Ortho
      • 11 Cardiac Arrest
      • Exam
      • Uworld 2
      • Uworld
    • Neuro
      • Alpha Synuclens
      • Anatomy
      • Back Pain
      • Brain
      • CNS Infections
      • Coma
      • Dementia And Movement
      • Dementia
      • Dizziness
      • Eye Problems
      • Headache
      • Localization
      • Malignancies
      • Neuro Exam
      • Neuromuscular
      • Neuropathy
      • Others
      • Overview
      • Seizures Notes
      • Seizures
      • Spinal Cord Syndromes
      • Stroke Meded
      • Stroke
      • Tremors
      • Uworld Neuro Notes
    • OB
      • 01 Abnormal Pap
      • 01 Cancer
      • OB Cases
      • OB Uworld
    • Pediatrics
      • 01 Newborn Management
      • 02 NICU
      • 03 Failure To Pass Meconium
      • 04 Emesis
      • 05 Neonatal Jaundice
      • 06 Congenital Defect
      • Well Child
      • Vaccines
      • 09 SIDS
      • 10 Trauma
      • 11 Child Abuse
      • 12 Rashes
      • 13 Peds ID
      • 14 Allergies
      • 15 ENT
      • 16 Upper Airway
      • 17 Lower Airway
      • 18 Seizures
      • 19 GI Bleed
      • 20 CT Surgery
      • 21 Orthopedics
      • 22 Ophthalmology
      • Pediatric Nephrology
      • Pediatric Sickle Cell
      • 25 Immunodeficiency
      • Ambulatory
      • Genetic Syndromes
      • Misc
      • Neonatal Rashes
      • Newborn Nursery
      • Pretest Adolescent
      • Pretest Cardiorespiratory
      • Pretest Endocrine
      • Pretest GI
      • Pretest Infectious Disease
      • Pretest Neuro
      • Pretest Newborn
      • Pretest
      • PTT Vs Anti Xa
      • Uworld
      • Wards
    • Psych
      • Anxiety Disorders
      • Childhood Psychiatry
      • Dementia Delirium
      • Dissociative Disorders
      • Eating Disorders
      • EEG
      • Factitious Disorders
      • Impuse Control
      • Legal Psychiatry
      • Mood Disorders
      • Nonpharm Treatment
      • Personality Disorders
      • Psychiatric Exams
      • Psychopharmacology
      • Psychosis Ddx
      • Psychotic Disorders
      • Sexual Disorders
      • Sleep Disorders
      • Substance Abuse
      • Uworld Psych
      • Week 2
    • Surgery
      • 01 Ethics
      • 01 Trauma
      • 02 Colorectal
      • 02 Pediatric
      • 03 Burns
      • 03 Gyn
      • 04 Postoperative
      • 05 Preoperative
      • 06 Trauma
      • 07 Burns
      • 08 Cardiology
      • 09 Colorectal
      • 10 Dermatology
      • 11 Endocrine
      • 12 ENT
      • 13 ER
      • 14 General Surgery
      • 15 GI
      • 17 Infectious Disease
      • 18 Nephrology
      • 19 Neuroendocrine Tumors
      • 20 Orthopedics
      • 21 Pulmonary
      • 22 Shock
      • 23 Transplant
      • 24 Urology
      • 25 Breasts
      • 25 Vascular
      • Fluids
      • GI Autonomics
      • Notes
      • Review
    • Uworld
      • Class Notes
      • Step 2 Uworld 1
      • Uworld 2
      • Uworld 3
      • Uworld 4
      • Uworld 5
  • 03 Residency
    • 01 Insulin
    • 02 ICU
    • 03 Electrolytes
    • 04 Sedation
    • 05 Wards
    • 06 Acid Base
    • Orientation Notes
    • Prescription Writing
Powered by GitBook
On this page
  • DLCO
  • Poor Breathing Mechanics
  • Interstitial Lung Disease
  • IPF
  • Pneumoconiosis
  • Drug
  • Hypersensitivity

Was this helpful?

  1. 01 Step 1
  2. Pulmonary

11 Restrictive

Previous10 ObstructiveNext12 COPD Treatment

Last updated 5 years ago

Was this helpful?

..

DLCO

  • normal DLCO: alveoli working

  • emphysema: destruction of alveoli, low DLCO

  • abnormal vasculature with impaired ability of blood to pick up CO

  • lung resection: healthy alveoli, just less

  • anemia: not enough RBC to pick up CO

  • asthma: high DLCO due to more capillaries

Poor Breathing Mechanics

Interstitial Lung Disease

  • pathologic process starting in interstitium, misleading because often involves destruction of alveoli

  • sticky, fibrous, inflammatory tissue, prevents lung inflation

  • right: streaky infiltrates with dark stuff (honeycombing)

  • left: white stuff with holes (honeycombing)

  • IPF: fibrous tissues diffusely laid down in lungs, hard to breath

  • scleroderma/RA can involve lung

  • Goodpasture/Wegener: antibodies involve lung

  • sarcoidosis: granulomas inside lung

IPF

  • collection of different disorders

Pneumoconiosis

Coal Miner

  • upper lobe preference

Silicosis

  • metal castings made of silica

  • high TB prevalence in silicosis

  • Silicosis is distinguished by calcification of the rim of hilar nodes (eggshell calcification) and birefringent silica particles surrounded by fibrous tissue on histology. It has long been associated with increased risk of tuberculosis.

    Silicosis impairs the macrophage effector arm of cell-mediated immunity, which is integral to the immune response against mycobacteria. It is thought that macrophage phagolysosomes are disrupted by internalized silica particles, causing release of the particles and viable mycobacteria, which inhibits the immune system's ability to control the infection. This extracellular release of lysosomal enzymes is thought to contribute to alveolar and interstitial lung injury in silicosis. Prolonged exposure of macrophages to silica particles also appears to increase macrophage apoptosis.

  • well circumscribed

Asbestosis

  • asbestos: for insulation

  • pleural plaques: white arrow

  • white stuff at edges (black arrow)

  • see white at edges in occupational worker, think asbestosis

  • left: after phagocytosed

  • greatest risk is bronchogenic carcinoma

  • see pleural effusion in asbestosis worker, think mesothelioma

  • chest pain: pleural involved, stretched

Drug

  • Fibrotic lung embroidery: amiodarone can cause pulmonary fibrosis

  • Tight button: amiodarone induced lung fibrosis causes restrictive lung disease

  • Beluga whale: bleomycin (antitumor antibiotic)

  • Lung coral: bleomycin can cause pulmonary toxicity (e.g. pneumonitis, pulmonary infiltrates)

  • Beautiful sirens: busulfan (cytotoxic alkylating agent)

  • Fibrotic lung pattern: busulfan can cause lung toxicity (e.g. acute lung injury, interstitial fibrosis, alveolar hemorrhage)

  • Fibrotic lung bonsai: MTX can cause pulmonary fibrosis (restrictive lung disease)

Hypersensitivity

..

..

..

..

..

..

..

_
_
_
_
_
_
_
_