13 FA

Synthesis

• acetyl coa can be used for FA synthesis but can't cross membrane

• citrate also inhibit glycolysis once in cytosol

• malonyl coa inhibit beta oxidation so no breakdown of FA while synthesis

Breakdown

Glycerol

• glycerol travel to liver and converted to glycerol-3-phosphate

FA

• adds coA molecule

• increased requirements from high metabolism

• can't breakdown FA

• cardiomyopathy: heart also needs FA

• can only use glucose: hypoglycemia

• cannot make ketones

• normally hypoglycemic = high levels of ketone bodies

• can't move carnitine

• has carnitine

• build up of FA

• high levels of acyl carnitine

• dicarboxylic acids made via omega oxidation

• even chain: metabolize until gone