Malaria

Life cycle

• sporozoite infectious form

• not get sick for several weeks

• schizonts: many nuclei, ready to rupture

• in liver, hasn't reached RBC

• daughter cells

• can see on blood smears

• cyclic fever whenever schizonts rupture

• erythrocyte cycle cause of fever pattern

Symptoms

Vivax

• primaquine the one drug that treats vivax, doesn't treat active cell

Malariae

Falciparum

Diagnosis

Protection

• Duffy antigen on RBC necessary for infection

Treatment

• plasmodium converts Hgb heme to nontoxic form using heme polymerase

• mefloquine prophylaxis for travelers. Very vivid dreams SE