Hypersensitivity

Type 1

• allergies

• non receptor tyrosine kinase

• epinephrine: vasoconstrict, increase CO, dilate bronchioles

• genetic. Multiple sensitivities

• leukotrienes can be produced quickly as early phase or later as late phase

• chymase, tryptase specific for anaphylaxis, not serotonin

• wheal: raised red skin

Type 2

Type 3

• deposit of complex

• complex deposits in lots of places, causing systemic diseases

Arthus

• don't circulate

• form in tissue locally and cause disease

• inject first time, no reaction. Third or fourth time, arthus

• first 3 times, antibody formation. 4th time: reaction

• booster vaccine: antigen into someone previously exposed to vaccine

• diabetes repeatedly inject insulin

Type 4