02 Purine

• direct synthesis from building blocks

• salvage: breaks down DNA, salvage bases

• amino: amine group

Purine Synthesis

• A and G: nitrogen group

• adding phosphate groups to 1 C

• THF from vitamin folate, important for thymidine and purine

• folate: single carbon donor

Salvage

• salvaging pathway inhibited

Excretion

• under excretion: furosemide

• overproduction