08 Acid Base Principles
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Equilibrium constantly in plasma
pH at set point
low bicarb, drive equation right, make more H, acidic
don't memorize
bicarb up, pCO2 down, increase pH
bicarb down, pCO2 up, lower pH
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sample taken in arterial sys, radial a, for accurate pCO2
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blow CO2 off
drop CO
high CO2 = narcotic (people with pneumonia die painless death from high CO2 in older times)
Bohr effect:
less saturation at any level
H push O2 off hemoglobin
O2 more easily leave
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shift curve to left
[](. <img src='images/EaOaAtZ.jpg' alt='' /> .)..
[](. <img src='images/5hb7jar.jpg' alt='' /> .)..
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buffers prevent low pH from killing kidney
vomiting: alkalotic. Diarrhea: acidotic
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any kind of meta acidosis, compensation is respiratory alka
[](. <img src='images/JqAnE9t.jpg' alt='' /> .)..
simple metabolic acidosis with no secondary disorder
[](. <img src='images/QelIbe3.jpg' alt='' /> .)..
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[](. <img src='images/KEMbbst.jpg' alt='' /> .)..
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acute: within minutes, intracellular buffer soaks up acid via hemoglobin, more HCO3
[](. <img src='images/Ocz38yW.jpg' alt='' /> .)..
low yield. Don't memorize
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high altitude, respiratory alkalosis
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special: respiratory acidosis and metabolic alkalosis or metabolic acidosis and alkalosis
