05 Pedigree

• affecting both male/female

• most people don't have disease

• middle: both people don't have disease but are carriers

AD

• males/females affected

• 50% offspring have disease

• male to male transmission occurs (pass Y), not X linked

X linked

• one of X becomes inactive

• different cells in females will have different lyonization

• skewed lyonization: more healthy X become lyonized

X Dominant

Mitochondrial

• confusion from CNS effects

• lactic acidosis from no aerobic metabolism

Polygenetic