02 T Cells

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• polysaccharide capsules not recognized

Antigen presentation

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• requires antigen presentation:

TCR

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• CD3: E and Delta

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• CD4: quarterback of immune response

CD4

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MHC II

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Co-Stimulation

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TH1 and 2

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• macrophages secretes IL-12

T Cell cytokines

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TH1 vs 2

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• Population of T cells; local cytokines favoring one or the other

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• intracellular infections protected from antibodies because inside cell, Th2 not useful, Th1 cell mediated useful

Granulomas

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Leprosy

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IBS

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TH1 and macrophages

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• mutation in IL-12 or IFN-gamma receptors can lead to problem

IL12R deficiency

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IFN-y

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CD8

[_](CD8 T cell function. What cells have MHC I. What cells don't. Why is CD8 important)..

• antibody, APC, macrophages, CD4 are ineffective against intracellular virus

• CD8 react to MHC I and kill cell

MHC I

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• heavy chain = alpha

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CD8 function

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Regulatory T

[_](Regulatory T cells function, marker, CD's, cytokines)..

TH17

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Memory T

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• PPD test example of memory cell response

PPD

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Superantigens

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Thymus

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• positive selection selects for strongest binding to MHC

• negative selection selects for weakest binding to self antigens

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Aire

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