19 Nonhodgkin Lymphoma
Last updated
Last updated
classified in many ways
last 2: T cells
different in different places of lymph nodes
follicles: follicular lymphoma
region surround follicle: mantle, mantle cell lymphoma
marginal zone: outside mantle, marginal zone lymphoma
really difficult to recognize by cell
lymphoid follicle structure obliterated
large crab marching up to archers in stronghold (B cells in lymphoma): AIDS can cause Diffused Large B Cell Lymphoma
testicular lymphoma
B cell make antibodies: heavily use IgG H chain, over express BCL 2 next to it
Germinal center B cell frequent apoptosis with lack of BCL2
Now: does not die
feared outcome: convert to diffuse large B
abundance of follicles
histology shows centrocytes
presence of macrophages seen in reactive lymphadenopathy
reactive: some develop more than others
different in different places of lymph nodes
follicles: follicular lymphoma
region surround follicle: mantle, mantle cell lymphoma
marginal zone: outside mantle, marginal zone lymphoma
cells grow rapidly, unregulated growth
different in different places of lymph nodes
follicles: follicular lymphoma
region surround follicle: mantle, mantle cell lymphoma
marginal zone: outside mantle, marginal zone lymphoma
marginal zones form and expands in settings of chronic inflammation
found in portions of bodies where chronic inflammation occurs
can present with swollen lymph nodes and very high WBC count, like leukemia
rapidly dividing cells, create lots of debrid cleaned up by macrophages, clearing spaces
cancer cells with white areas
Africa/New Guinea: high prevalence of EBV
sporadic: any country
B tumors association with latent EBV
AA bar kid with swelling jaw: Endemic or African Burkitt lymphoma = large jaw lesion and swelling
lymphocytosis: leukemia
lymphadenopathy: lymphoma
rule of thumb: T cells involve skin
MM: no LAD, skin lesions, lymphocytosis, endemic location
mycosis: nothing to do with fungal infection
malignant cells enter blood stream
