20 Gastric

• erosion does not break through muscularis mucosa

Gastritis

• acute: neutrophil

• chronic: lymphocytes/plasma/macrophages

• acute: acid

• chronic: autoimmune or H. pylori

• dyspepsia: indigestion

Acute Gastritis

• parietal: body/fundus, not antrum

• H. Pylori: most commonly chronic, but can cause acute

• loss of blood flow

• PPI to burn pts

Chronic

Pernicious Anemia

• affects only body/fundus, where parietal cells are

Type B

• doesn't invade mucosa, sits on top, form protective barrier

• biopsy of lining of stomach

• urea split into CO2

• metaplasia, atrophy of stomach lining

• leads to adenocarcinoma

Peptic Ulcer

• increased acid from H. pylori

Duodenal Ulcers

• G cells sensing alkaline env in antrum

• pancreas just behind posterior wall

• vomiting of coffee ground material

Gastric Ulcers

• dangerous cause of gastric ulcer: adenocarcinoma

Treatment

Carcinoma

Intestinal

Diffuse

• entire stomach thickened. Early satiety

• suddenly develop keratoses

• diffuse type of adenocarcinoma

Dyspepsia

Hypertrophic Gastropathy

• like HCM

Menetrier

• low protein leads to hypoalbuminemia

• case: abd pain, edema, facial swelling, low albumin, large stomach on CT