> For the complete documentation index, see [llms.txt](https://thisispiggy.gitbook.io/my-wiki/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://thisispiggy.gitbook.io/my-wiki/01-step-1/heme/18-hodgkin-lymphoma.md).

# 18 Hodgkin Lymphoma

## Lymphoma

![](https://f001.backblazeb2.com/file/wikiFiles/Nb7mrOD.jpg)

* lymphocytes form mass: oma

![](https://f001.backblazeb2.com/file/wikiFiles/dmc5qBB.jpg)

* painful: reactive lymph nodes in infection

![](https://f001.backblazeb2.com/file/wikiFiles/9UDrb6j.jpg)

* tissue biopsy of mass/lymph node

## Reed-Sternberg

![](https://f001.backblazeb2.com/file/wikiFiles/iD6MBss.jpg)

* Hodgkins

![](https://f001.backblazeb2.com/file/wikiFiles/AFlnjVQ.jpg)

## Hodgkin Lymphoma

![](https://f001.backblazeb2.com/file/wikiFiles/hRLny7Q.jpg)

* autoimmune: immune activation

![](https://f001.backblazeb2.com/file/wikiFiles/f98eyJq.jpg)

* Owl sitting in weeds: Hodgkin lymphoma = Reed-Sternberg cells that look like "owl's eyes"

![](https://f001.backblazeb2.com/file/wikiFiles/pHAMAfE.jpg)

* reed sternberg only a small amt of cell in lymph nodes
* most cells are reactive cells reacting to cytokines from reed sternberg: B symptoms more common
* one of the reactive cells: macrophages, containing 1a hydroxylase

![](https://f001.backblazeb2.com/file/wikiFiles/jfhFv17.jpg)

* spread from 1 set of nodes to another, very predictable

![](https://f001.backblazeb2.com/file/wikiFiles/HuYNznP.jpg)

* most pt classical form

![](https://f001.backblazeb2.com/file/wikiFiles/utlga7u.jpg)

* variant of reed sternberg: popcorn cells

![](https://f001.backblazeb2.com/file/wikiFiles/s5mIZXF.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/bdM3v96.jpg)

* tumor forms fibrosis tissues that surrounds tumor, creating nodules

![](https://f001.backblazeb2.com/file/wikiFiles/bbABbrX.jpg)

* mixed cellularity: lots of eosinophils
* more the lymphocytes, better prognosis

![](https://f001.backblazeb2.com/file/wikiFiles/EYm4TLQ.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/hQ1MO35.jpg)

* enlargement often in nonhodgkin

![](https://f001.backblazeb2.com/file/wikiFiles/TXWA5YF.jpg)

* most common regimen
* don't memorize