18 Hodgkin Lymphoma

Lymphoma

• lymphocytes form mass: oma

• painful: reactive lymph nodes in infection

• tissue biopsy of mass/lymph node

Reed-Sternberg

• Hodgkins

Hodgkin Lymphoma

• autoimmune: immune activation

• Owl sitting in weeds: Hodgkin lymphoma = Reed-Sternberg cells that look like "owl's eyes"

• reed sternberg only a small amt of cell in lymph nodes

• most cells are reactive cells reacting to cytokines from reed sternberg: B symptoms more common

• one of the reactive cells: macrophages, containing 1a hydroxylase

• spread from 1 set of nodes to another, very predictable

• most pt classical form

• variant of reed sternberg: popcorn cells

• tumor forms fibrosis tissues that surrounds tumor, creating nodules

• mixed cellularity: lots of eosinophils

• more the lymphocytes, better prognosis

• enlargement often in nonhodgkin

• most common regimen

• don't memorize