14 Liver Disease

Tests

• enzyme in liver that transfer nitrogen groups between amino acids

• can use to see if pts drinking

• 5'-nucleotidase similar enzyme

• low

Alcoholic

• chronic leads to cirrhosis

Fatty Liver Disease

• liver enlarged in heavy drinker = fat deposition

NAFLD

Acute Hepatitis

Budd Chiari

• ascites: blood can't drain, push into portal system, out into abdomen

• hepatocellular carcinoma: liver tumor compresses cells into hepatic vein

RHF

Reye

a1 antitrypsin

• purple deposits

• glycogen also stain purple

Abscess

Hepatitis

Autoimmune

Tylenol

• right after ingestion: activated charcoal

Shock

Things cause >1000 ALT/AST:

• hepatitis

• tylenol

• shock