05 Pharmacokinetics

• method apply drug affect how much bioavailable

• percent to blood stream

• compare area under curve for oral with area under curve for IV

• 1st steep decline: reaching steady state in body

• C0: concentration if drug immediately distribute equally in body

• large/charged: can't leave vascular compartment

• chloroquine: large amount in tissue, little in blood stream. Back calculation = large number

• greater effects/SE when more unbound drug move to tissues

• metabolized/excreted faster

• elimination constant: how quickly kidney clears a volume of plasma

• greater the volume of distribution, greater the clearance (remove same number of molecules but in more plasma)

• clearance not amount of drug held by kidney but amount of volume cleared of drug

• higher the clearance, higher elimination constant

• 4 half lives to get drug out of body

• immediately to 20