05 Hypoxia

O2 Delivery

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• saturation of hemoglobin depends on PaO2

PaO2

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• in arteriole blood

• measures dissolved

• measures saturation

• saturation of hemoglobin depends on PaO2

Hypoxia

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• hypoxemia: low number calculated from equation

• hypoxia can be caused by hypoxemia and other things

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HF

• hypoxia or ischemia

• pulmonary edema with CHF: may have reduced O2 content

Anemia

• O2 binding capacity reduced

• not enough Hb around

CO

• functional anemia: taking Hb away from O2

Alveolar Gas

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• PAO2: O2 partial pressure in alveoli, lower because O2 exchange

• PaO2: lower because mixing of blood from vessels travel through lungs and do not go through alveoli

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• gas exchange

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• high altitude: low partial pressure of O2