09 AD

AD

_.. Autosomal Dominant _.. Autosomal Dominant _.. Autosomal Dominant _.. Autosomal Dominant _.. Autosomal Dominant _.. Autosomal Dominant _.. Autosomal Dominant _.. Autosomal Dominant _.. Autosomal Dominant _.. Autosomal Dominant _.. Autosomal Dominant _.. Autosomal Dominant _.. Autosomal Dominant _.. Autosomal Dominant

X

_.. X Linked _.. X Linked _.. X Linked _.. X Linked _.. X Linked _.. X Linked _.. X Linked _.. X Linked _.. X Linked _.. X Linked

AR

_.. Autosomal Recessive _.. Autosomal Recessive _.. Autosomal Recessive _.. Autosomal Recessive _.. Autosomal Recessive _.. Autosomal Recessive _.. Autosomal Recessive _.. Autosomal Recessive _.. Autosomal Recessive _.. Autosomal Recessive _.. Autosomal Recessive _.. Autosomal Recessive

HLA

_DR2, 3., _B8, DR3., _B8, DR3, 4., _DR3, 4., _DR3, 5., _DQ2, 8., _B8., _B27., _DR2., _DR3., _DR4., _DR5.,

Oncogenes

_ Receptor tyrosine kinase.

Lung adenocarcinoma.,

Oncogene

_ Tyrosine kinase.

CML, ALL.,

Oncogene

_ Antiapoptotic molecule (inhibits apoptosis).

Follicular and diffuse large B cell lymphomas.,

Oncogene

_ Serine/threonine kinase.

Melanoma, non-Hodgkin lymphoma, papillary thyroid carcinoma.,

Oncogene

_ Cytokine receptor

Gastrointestinal stromal tumor (GIST).,

Oncogene

_ Transcription factor

Burkitt lymphoma.,

Oncogene _ Receptor tyrosine kinase

Breast and gastric carcinomas.,

Oncogene

_ Tyrosine kinase

Chronic myeloproliferative disorders.,

Oncogene

_ GTPase

Colon cancer, lung cancer, pancreatic cancer.,

Oncogene

_ Transcription factor

Lung tumor.,

Oncogene

_ Transcription factor

Neuroblastoma.,

Oncogene

_ Receptor tyrosine kinase

MEN 2A and 2B, medullary thyroid cancer.,

Oncogene

Tumor Suppressors

_ Negative regulator of β-catenin/WNT pathway

Colorectal cancer (associated with FAP).,

Tumor suppressor

_ DNA repair protein

Breast, ovarian, and pancreatic cancer.,

Tumor suppressor

_ p16, blocks G1 to S phase

Melanoma, pancreatic cancer.,

Tumor suppressor

_Deleted in Colon Cancer

Colon cancer.,

Tumor suppressor

_Deleted in Pancreatic Cancer

Pancreatic cancer.,

Tumor suppressor

_ Menin

MEN 1.,

Tumor suppressor

_ Neurofbromin (Ras GTPase activating protein)

Neurofibromatosis type 1.,

Tumor suppressor

_ Merlin (schwannomin) protein

Neurofibromatosis type 2.,

Tumor suppressor

_ Tyrosine phosphatase of PIP3 (eg, protein kinase B [AKT] activation)

Breast cancer, prostate cancer, endometrial cancer.,

Tumor suppressor

_ Inhibits E2F; blocks G1 p S phase

Retinoblastoma, osteosarcoma.,

Tumor suppressor

_ p53, activates p21, blocks G1 to S phase

Most human cancers, Li-Fraumeni syndrome.,

Tumor suppressor

_ Hamartin protein

Tuberous sclerosis.,

Tumor suppressor

_ Tuberin protein

Tuberous sclerosis.,

Tumor suppressor

_ Inhibits hypoxia inducible factor 1a

von Hippel-Lindau disease.,

Tumor suppressor

_ Transcription factor that regulates urogenital development

Wilms tumor nephroblastoma.,

Tumor suppressor

_ SBLA cancer syndrome: Sarcoma, Breast, Leukemia, Adrenal gland..