03 Renal Physiology 1

Fluid

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• only in extracellular space, injected

• albumin: only in plasma, not interstitial

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• only portion of fluid perfusing tissues

• theoretical volume

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• TBW: total body water

Kidney Function

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• sufficient urine = kidney working, but very crude measurement

• filtration fraction: percentage of all blood in kidney filtered

• FF: RPF not RBF

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• yellow: bowman space

• left: high osmotic pressure

• right: low osmotic pressure

• high pressure draw water away from low pressure side

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• high oncotic pressure in glomerulus, but even higher hydrostatic pressure that drive water out into bowman's space

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• FF same

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• decreased renal plasma flow overall, less blood perfusion kidney

• increase FF

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• multiple myeloma

• same amount of blood in and out of kidney (afferent = efferent)