Glucocorticoids

Eicosanoids

• eicosanoids include leukotrienes, PGs, TXs

• block PGE2: improvement in first 4 conditions with price of renal vasoconstriction

COX

Drugs

NSAIDS

• effects similar to steroids but not steroids

• ketorolac: often IM in ER for pain

• traditional NSAIDS

COX2

Steroids

• TNF alpha works by activating NF-KB

• feared complication