02 Wallerian Degeneration

Peripheral

  • trauma

  • arms/legs

  • mild damage: neurapraxia

Neurapraxia

  • Continuity: rest of nerve not severed

Neurotmesis

  • entire nerve damaged, including epineurium

Axonotmesis

  • nerve distal and proximal to lesion react differently

  • axonal regrowth happens if schwann cell is intact

CNS

Injury

  • ischemia

  • red neurons = ischemia

  • cyst walled off by astrocytes

UMN vs LMN

  • 3+ reflex

Bulbar

  • face and neck

  • bulbar palsy or symptoms

  • bulbar palsy: LMN palsy of bulbar

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