Pediatric Sickle Cell

Pathogenesis

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Labs

Baseline changes:

• increased bilirubin, reticulocytes

• decreased Hgb

• chronic pain

Diagnosis

• prenatal screen

• CBC: sickle cells

• Hgb electrophoresis

Treatment

• acute crisis: increased pain, sickling, lab changes

  • IVF, O2 for hypoxia, control pain, antibodies for infection

• acute crisis without lab changes:

  • psychosocial management