05 Platelet Disorders
Last updated
Last updated
superficial bleeding
nl aggregation with ristocetin test
large platelets on smear
abnormal ristocetin assay
ITP
TTP
HUS
DIC
Uremia
thrombocytopenia
vWF
Hayde's
don't live as long as they should = low number
macrophages clear antibody bound platelets
platelet thrombi: platelet low, coagulation factors not consumed
much more dangerous
low platelets, thrombosis
thrombus form in small vessels, consumes platelets, thrombocytopenia
TTP: build up of platelets and RBC, obstruction
small vessel occlusion in CNS
thrombi primarily made of platelets, do not consume clotting factor
platelet thrombi: platelet low, coagulation factors not consumed
distinguish from TTP: no fever or CNS symptoms (TTP only with kidney)
platelet thrombi: platelet low, coagulation factors not consumed
both platelets and fibrin, increased PT, PTT
TF activate coagulation cascade
sepsis: high levels of cytokines and endotoxins
every blood test abnormal
platelet thrombi: platelet low, coagulation factors not consumed
caused by toxins, not platelets
heavy periods common early presentation
ristocetin test normal in glanzman
ristocetin test also abnormal in Bernard
aortic stenosis: increased risks of angiodysplasia
overactivity of ADAMST13, breaking down multimers, causing VWF to be less efficient