> For the complete documentation index, see [llms.txt](https://thisispiggy.gitbook.io/my-wiki/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://thisispiggy.gitbook.io/my-wiki/01-step-1/heme/05-platelet-disorders.md).

# 05 Platelet Disorders

## Inherited

![](https://f001.backblazeb2.com/file/wikiFiles/8ZEWR3w.jpg)

### Glanzman's

![](https://f001.backblazeb2.com/file/wikiFiles/kGPUWCf.jpg)

* superficial bleeding
* nl aggregation with ristocetin test

### Bernard

![](https://f001.backblazeb2.com/file/wikiFiles/BZypoMZ.jpg)

* large platelets on smear
* abnormal ristocetin assay

![](https://f001.backblazeb2.com/file/wikiFiles/3gFmTpC.jpg)

### Wiskott- Aldrich

![](https://f001.backblazeb2.com/file/wikiFiles/ofJ93TG.jpg)

## Acquired

* ITP
* TTP
* HUS
* DIC
* Uremia
* thrombocytopenia
* vWF
* Hayde's

### ITP

![](https://f001.backblazeb2.com/file/wikiFiles/h6UEXib.jpg)

* don't live as long as they should = low number
* macrophages clear antibody bound platelets

![](https://f001.backblazeb2.com/file/wikiFiles/DZtwuP3.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/10Xrh1V.jpg)

* platelet thrombi: platelet low, coagulation factors not consumed

### TTP

![](https://f001.backblazeb2.com/file/wikiFiles/XfsfewP.jpg)

* much more dangerous
* low platelets, thrombosis
* thrombus form in small vessels, consumes platelets, thrombocytopenia

![](https://f001.backblazeb2.com/file/wikiFiles/kZK9uKx.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/bsYGOM2.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/HJxht7L.jpg)

* TTP: build up of platelets and RBC, obstruction

![](https://f001.backblazeb2.com/file/wikiFiles/wu55JCZ.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/S27wjXx.jpg)

* small vessel occlusion in CNS

![](https://f001.backblazeb2.com/file/wikiFiles/2ItD73a.jpg)

* thrombi primarily made of platelets, do not consume clotting factor

![](https://f001.backblazeb2.com/file/wikiFiles/10Xrh1V.jpg)

* platelet thrombi: platelet low, coagulation factors not consumed

![](https://f001.backblazeb2.com/file/wikiFiles/GjaPpuq.jpg)

### HUS

![](https://f001.backblazeb2.com/file/wikiFiles/tqcsx57.jpg)

* distinguish from TTP: no fever or CNS symptoms (TTP only with kidney)

![](https://f001.backblazeb2.com/file/wikiFiles/10Xrh1V.jpg)

* platelet thrombi: platelet low, coagulation factors not consumed

### DIC

![](https://f001.backblazeb2.com/file/wikiFiles/o3zOq2u.jpg)

* both platelets and fibrin, increased PT, PTT

![](https://f001.backblazeb2.com/file/wikiFiles/ezwMHNG.jpg)

* TF activate coagulation cascade
* sepsis: high levels of cytokines and endotoxins

![](https://f001.backblazeb2.com/file/wikiFiles/XAHjUkI.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/rytAGo9.jpg)

* every blood test abnormal

![](https://f001.backblazeb2.com/file/wikiFiles/0moASbM.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/10Xrh1V.jpg)

* platelet thrombi: platelet low, coagulation factors not consumed

### Uremia

![](https://f001.backblazeb2.com/file/wikiFiles/VWNk4x5.jpg)

* caused by toxins, not platelets

### Thrombocytopenia

![](https://f001.backblazeb2.com/file/wikiFiles/6KjJGS4.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/DIkU16w.jpg)

### Von Willebrand

![](https://f001.backblazeb2.com/file/wikiFiles/ZrgXMS5.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/brda5uv.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/U4fK4JW.jpg)

* heavy periods common early presentation

![](https://f001.backblazeb2.com/file/wikiFiles/7a9iJvd.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/sR6eZBF.jpg)

* ristocetin test normal in glanzman
* ristocetin test also abnormal in Bernard

![](https://f001.backblazeb2.com/file/wikiFiles/1BHxHbz.jpg)

### Hayde's

![](https://f001.backblazeb2.com/file/wikiFiles/s4EF1vV.jpg)

* aortic stenosis: increased risks of angiodysplasia
* overactivity of ADAMST13, breaking down multimers, causing VWF to be less efficient