05 Translation
mRNA from 5 to 3
1st amino acid at 5' cap is read first
protein synthesis antibiotics target ribosomes only found in prokaryotes
not normal bases found in RNA. Very unusual shape
base pairs with itself within the molecule
genetic code: codon on mRNA, coding strand
tRNA: anticodon, complementary to genetic code
thymidine normally not found in RNA. Also normally no OH
aa to 3' end of tRNA
2 phosphate lost from ATP. AA combined with AMP
AMP split off, amino acid added
formation of aminoacyl group via aminoacyl-tRNA synthetase
hydrolyze and cleave aa off from AMP/tRNA and not added to chain
each site is a codon on mRNA strand
methionine in eu. fMet in bacteria
tRNA for met or fMet binds directly to P site
met removed later
catalyzed by the ribosome itself
peptidyl transferase: made of RNA not proteins
no tRNA with anticodons to these codons
OH group at end of molecule
N-: sugar to nitrogen, etc.
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