24 Diuretics

• body maintain 140 meq concentration via water retention/excretion

CA Inhibitors

• almost never used as diuretics because effect so weak

• paresthesia common in a number of acid-base disorders (acid-base disruption on nerves)

• calcium stones from acidemia that prevents citrate excretion

Osmotic Diuretics

• can't excrete mannnitol, circulate in plasma for long time

• also cause anuric renal failure (no urine)

Loop

• really strong, use in edematous state to remove volume

• decrease gradient of interstitium in inner medulla

Thiazide

• inhibit NaCl pump, Na/K pump still active, low intracellular Na

• NaCa exchanger active, lower intracellular Ca

• Ca pulled from lumen

• hyperGLUC mnemonic

• don't produce vigorous output, not good for edematous state

K sparing