> For the complete documentation index, see [llms.txt](https://thisispiggy.gitbook.io/my-wiki/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://thisispiggy.gitbook.io/my-wiki/01-step-1/infectious-disease/03-bacteria-virulence.md).

# 03 Bacteria Virulence

## Virulence factors

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/Virulence%20factors%20are%20and%20examples/README.md)..

![](https://i.imgur.com/ZLfOmQH.jpg)

### Protein A

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/protein%20A%20belongs%20to%20what%20bacteria%20and%20function/README.md)

![](https://i.imgur.com/O1M5wxg.jpg)

.,

![](https://i.imgur.com/ZSSmDBX.jpg)

### IgA Protease

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/IgA%20protease%20bacteria%20and%20function/README.md)..

![](https://i.imgur.com/DRC3pt7.jpg)

### M Protein

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/M%20protein%20bacteria%20and%20function/README.md)

![](https://i.imgur.com/JHFDJ9z.jpg)

![](https://i.imgur.com/ziJ9YXl.jpg)

* Prevents phagocytosis.,

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/M%20protein%20complications,%20how%20does%20it%20happen/README.md)

![](https://i.imgur.com/vsX59bX.jpg)

.,

## Endotoxin

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/Endotoxin%20components/README.md)..

* LPS with lipid A mostly responsible for toxicity
* O antigen do not cause disease by themselves

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/Endotoxin%20triggers%20what%20release%20and%20cause%20what%20problems.%20Temperature%20toleration?)..

![](https://i.imgur.com/xKNygmb.jpg)

![](https://i.imgur.com/ILdtEdG.jpg)

* c3a and c5a anaphylaxis reaction
* low bp: hypotension/shock

![](https://i.imgur.com/KRLyURz.jpg)

### LOS

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/LOS%20is,%20structures,%20found%20in%20what%20bacteria/README.md)..

* Lipooligosaccharide

![](https://i.imgur.com/ATzLMbg.jpg)

## Exotoxins

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/Exotoxin%20classic%20structure%20and%20function%20for%20each%20part/README.md)..

![](https://i.imgur.com/WkD7WDF.jpg)

### Protein synthesis inhibitors

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/Exotoxin,%20protein%20synthesis%20inhibitor%20bacterias/README.md)

![](https://i.imgur.com/uUp9nla.jpg)

.,

### ADP Ribosylation

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/overall%20MOA%20of%20ADP%20ribosylation%20toxins%20and%20what%20bacteria%20use%20this/README.md)..

![](https://i.imgur.com/L60avO9.jpg)

#### C. Diphtheria

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/C.%20diphtheria%20toxin%20MOA)..

![](https://i.imgur.com/yuhmTd3.jpg)

* ADP-ribose added to EF-2 from NAD that makes EF-2 nonfunctional

#### Pseudomonas aeruginosa

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/pseudomonas%20toxin%20MOA/README.md)..

![](https://i.imgur.com/zzTBiEW.jpg)

### Shigella

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/Shigella%20disease%20MOA/README.md)..

![](https://i.imgur.com/7SY2czT.jpg)

### EHEC

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/EHEC%20disease%20MOA/README.md)..

![](https://i.imgur.com/USSZQx8.jpg)

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/Shigella%20vs%20EHEC/README.md)..

![](https://i.imgur.com/oE2LRIK.jpg)

### Fluid Secretion Toxins

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/Bacteria%20with%20fluid%20secretion%20toxins/README.md)..

![](https://i.imgur.com/qkzx4hW.jpg)

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/Fluid%20secretion%20toxin%20overview%20MOA/README.md)..

![](https://i.imgur.com/p166cLn.jpg)

#### ETEC

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/ETEC%20toxins%20MOA/README.md)..

![](https://i.imgur.com/uAupfC5.jpg)

LT:

![](https://i.imgur.com/yF7FoBn.jpg)

ST:

![](https://i.imgur.com/a6fGW4q.jpg)

![](https://i.imgur.com/Y0ndKTz.jpg)

### Bacillus Anthrax

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/Bacillus%20anthrax%20toxins%20MOA/README.md)..

![](https://i.imgur.com/1C0CRux.jpg)

Anthrax ulcers with necrotic center and edema borders:

![](https://i.imgur.com/fDViVy6.jpg)

![](https://i.imgur.com/wDvtfHu.jpg)

### Phagocytosis Inhibitors

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/phagocytosis%20inhibiting%20toxin%20MOA%20and%20bacteria/README.md)..

![](https://i.imgur.com/7S96qU9.jpg)

### Neurotoxins

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/neurotoxin%20bacteria%20and%20MOA/README.md)..

![](https://i.imgur.com/psySlZj.jpg)

![](https://i.imgur.com/3ZSQ2fl.jpg)

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/C.%20tetani%20vs%20botulinum%20toxin%20MOA%20and%20symptoms)..

![](https://i.imgur.com/X17DF89.jpg)

### Cell membrane lysis toxin

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/Bacteria%20with%20toxin%20that%20lysis%20cell%20membrane/README.md)..

![](https://i.imgur.com/7ZaVwGk.jpg)

#### C. perfringens

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/C.%20perfringens%20toxin%20moa)..

![](https://i.imgur.com/5PFMxYA.jpg)

#### Strep pyogenes

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/Strep%20pyogenes%20toxin%20MOA%20and%20antibody%20use/README.md)..

* strep throat, rheumatic fever, glomerulonephritis

![](https://i.imgur.com/wHQzhsc.jpg)

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/2%20types%20of%20bacteria%20toxin%20that%20are%20not%20part%20of%20chromosomes.%20Came%20from%20where?)..

![](https://i.imgur.com/OAezqux.jpg)

* C. diphtheria: virus delivers DNA to bacteria

### Superantigens

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/Superantigens%20MOA%20and%20result/README.md)..

* directly connects MHC to TCR and activates multiple T cells.
* Result: vasodilation and shock

![](https://i.imgur.com/4vBSzsd.jpg)

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/Superantigen%20bacteria%20and%20toxin%20name/README.md)..

![](https://i.imgur.com/CrVTrz6.jpg)

#### TSST

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Infectious%20Disease/TSST%20symptoms%20and%20how%20to%20differentiate%20from%20sepsis.%20Classic%20scenario)

* Sepsis does not have diarrhea and desquamation..

![](https://i.imgur.com/h2vK1rc.jpg)