03 Bacteria Virulence

Virulence factors

_..

Protein A

_

.,

IgA Protease

_..

M Protein

_

• Prevents phagocytosis.,

_

.,

Endotoxin

_..

• LPS with lipid A mostly responsible for toxicity

• O antigen do not cause disease by themselves

_..

• c3a and c5a anaphylaxis reaction

• low bp: hypotension/shock

LOS

_..

• Lipooligosaccharide

Exotoxins

_..

Protein synthesis inhibitors

_

.,

ADP Ribosylation

_..

C. Diphtheria

_..

• ADP-ribose added to EF-2 from NAD that makes EF-2 nonfunctional

Pseudomonas aeruginosa

_..

Shigella

_..

EHEC

_..

_..

Fluid Secretion Toxins

_..

_..

ETEC

_..

LT:

ST:

Bacillus Anthrax

_..

Anthrax ulcers with necrotic center and edema borders:

Phagocytosis Inhibitors

_..

Neurotoxins

_..

_..

Cell membrane lysis toxin

_..

C. perfringens

_..

Strep pyogenes

_..

• strep throat, rheumatic fever, glomerulonephritis

_..

• C. diphtheria: virus delivers DNA to bacteria

Superantigens

_..

• directly connects MHC to TCR and activates multiple T cells.

• Result: vasodilation and shock

_..

TSST

_

• Sepsis does not have diarrhea and desquamation..