11 TCA

• products used where they are produced

• acetyl coa donates 2 C to TCA that are removed as 2 CO2, no net difference in carbons

• acetyl coa cannot be converted to glucose that's made from oxaloacetate because it doesn't donate any extra carbons

• even chain FA can be converted to acetyl coa, cannot increase oxaloacetate or make glucose

Citrate

• irreversible, regulated by ATP

• citrate important indicator of energy levels inside cell. High levels of ATP inhibits citrate metabolism

• lowers level of oxaloactate for citrate synthase = less acetyl coa used

• high acetyl coa also from FA oxidation

• result: shunted towards ketone

Isocitrate

A Ketoglutarate

Succinyl

• irreversible

• succinyl coa/NADH inhibit

Succinate

Fumarate

Malate

• transport NADH in for ETC and oxaloacetate out for gluconeogenesis

• donate electron from NADH to malate

• OAA regenerated outside via aspartate conversion