11 TCA
Last updated
Last updated
products used where they are produced
acetyl coa donates 2 C to TCA that are removed as 2 CO2, no net difference in carbons
acetyl coa cannot be converted to glucose that's made from oxaloacetate because it doesn't donate any extra carbons
even chain FA can be converted to acetyl coa, cannot increase oxaloacetate or make glucose
irreversible, regulated by ATP
citrate important indicator of energy levels inside cell. High levels of ATP inhibits citrate metabolism
lowers level of oxaloactate for citrate synthase = less acetyl coa used
high acetyl coa also from FA oxidation
result: shunted towards ketone
irreversible
succinyl coa/NADH inhibit
transport NADH in for ETC and oxaloacetate out for gluconeogenesis
donate electron from NADH to malate
OAA regenerated outside via aspartate conversion
