Scleroderma
Last updated
Last updated
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aka systemic sclerosis: stiff hard tissue
most autoimmune: tissue destrcution
scleroderma: fibroblast
limited aka CREST
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people will have raynaud by itself at first
heart: RBBB, LBBB, AV nodal
interstitial lung: fibrous tissue in lung
early in disease
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CREST can occur in diffused but main symptoms of limited
difficulty swallowing: collagen deposition in esophagus
LES: collagen deposition disrupts LES activity. Tone measured with esophageal monometry
achalasia: hypertonicity
women: especially on cheeks and forehead
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crest = centromere
rarely treated with anti inflammatory drugs
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sjogren: half of pts have sjogren
