07 Mycobacterium

Mycobacterium Tuberculosis

_..

  • Mycobacterium cowboy: acid-fast gunslinger

  • Fuschin color: Carbol fuchin stain

  • tassels: Mycolic acids

  • lowenstein general store: TB grows on Lowenstein-Jenses medium

  • air bellow: Obligate aerobe

_..

  • latent

  • miliary and systemic, multiorgan failure

  • reactivation

_..

  • Primary TB: infects middle or lower lobe of lung

  • Primary TB: Hilar lymph node calcification

  • cactus with holes in middle lobe and hilar involvement, gun complex: Ghon complex: Hilar lymphadenopathy + peripheral granulomatous lesion in middle or lower lung lobe

_..

  • Proliferates in macrophages

  • cord: cord factor (serpentine shaped) secreting TNF-a to activate macrophages and walled off in granuloma

  • spur and clouds: Sulfatides (spurs), phagosome and lysosome unable to fuse

  • broken down carts: Necrotic macrophages, caseating granulomas

_..

  • sleeping kid: Latent infection common after primary infection kids

  • sleeping kid with sac: Fibrosis

  • shovel: Positive PPD test

_..

  • BCG vaccine can cause a false positive skin test

_..

  • Millet seeds everywhere: Miliary TB

  • cow skull: Miliary TB can be lethal

_..

  • TNF guy bound: neurtralized TNF > reactivation

  • Reactivation with TNF alpha inhibitors

  • guy coughing blood and sweating at night: Symptoms of reactivation: cough, hemoptysis, night sweats

  • wasting from TNF alpha

  • 2nd cactus: Reactivated TB: affects upper lung lobes

_..

  • bullet in hat: CNS involvement with cavitary lesion or tuberculoma

  • pots damaged: Pott's disease, multiple vertebrae affected, demineralization of bone, soft tissue swelling

_..

  • RIPE: Rifampin, isoniozid, pyrazinamide, ethambutol

  • Rifampin and isoniazid for prophylaxis

Mycobacterium Leprosy

_

aka Hansen's disease.,

_..

  • tassles: Mycolic acids

  • Mycobacterium cowboy: Acid-fast gunslinger

  • gun: Carbol fuchsin stain

_..

  • armadillo jail and armadillo: Armadillo is main reservoir in United States

  • Winter scene: Thrives in cool temperatures: predilection for extremities

_..

  • tuberculoid

  • lepromatous

_..

  • Jail cell 1: Tuberculoid leprosy: Th1 response with cell mediated immunity

  • Jail: Tuberculoid leprosy: able to contain bacteria within macrophages

  • bald head: Tuberculoid leprosy: well-demarcated, hairless, hypoesthetic skin lesion

  • rifle and deputy: Treatment: Rifampin/dapsone

_..

  • shovel in dirt: Tuberculoid leprosy: positive Lepromin skin test, good cell mediated response

_..

  • Jail 2: Lepromatous leprosy: bacteria unable to be contained by macrophages

  • prisoner laughing: Lepromatous leprosy: Th2 mediated humoral response

  • touching hands: lepromatous human to human transmission

  • lion's face mask: Lepromatous leprosy: leonine facies

  • gloves: Lepromatous leprosy: symmetric glove and stocking neuropathy

  • skin lesions on arm/legs: Lepromatous leprosy: poorly demarcated raised lesions on extensor surfaces of extremities

  • clothe: Treatment: Clofazimine along with rifampin/dapsone

Previous06 Gm Negative Zoonotic BacilliNext08 Spirochetes

Last updated