Trinucleotide Disorders


polymorphic: many forms include variable number of repeats from person to person

more repeats with each generation
Fragile X





symptoms similar to down syndrome
Frederich's Ataxia

brain, heart, pancreas depend on mitochondria

Huntington

deacetylation

Myotonic Dystrophy

muscle disorder along with DMD, becker

loss of myotonic dystrophy protein kinase
CTG

later than other muscular dystrophies

triad: Cataracts, Toupee, Gonadal atrophy



as opposed to HF



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