04 Complement

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• great for encapsulated bacteria

C3

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• Overview of complement

• 3 different pathways, next step always MAC

Alternative Pathway

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• destroyed in less than a second if not bound

C3b

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• stable c3b creates more of itself via positive loop

Factor H

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Lectin Pathway

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Classical pathway

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• Alternative and MBL part of innate immunity

C1

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• IgM: 2 Fc very close together, easy C1 binding

• IgG: ok complement activation

CRP

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• binds C polysaccharides of bacteria

C3a C3b

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MAC

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• aka late complement

C5a

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Inhibition

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PNH

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• DAF/CD59 deficiency

• start at RBC lysis

• Free plasma Hgb thrombogenic

• Priapism: sustained prolonged erection

C3 Deficiency

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• immune complex: antigen-antibody, usually cleared via complement binding and macrophage

C5-9 deficiency

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• not as bad as c3 deficient

Hereditary Angioedema

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• c1 inhibitor breaks down bradykinin

• urticaria: histamine, not here

• Epinephrine doesn't work

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• ace inhibitor block bradykinin breakdown

  C3 Nephritic

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Hypocomplementemia

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• CH50: classic pathway lysis sheep RBC. Qualitative test, yes or no