Cell Cycle

• G1: first growth phase

• S: synthesize DNA

• M: mitosis

• G0: Quiescent phase

• M: mitosis (dividing) and I: interphase (not dividing)

• growth factor: grow in size

• mitogen: grow by division

• mitotic spindle: fibers and microtubules

• sister chromatids pulled to opposite ends

Cell Cycle Control

• within M phase

• first checkpoint very important: decision to commit growth

• cyclin D/CDK4 and 6, and cyclin E/CDK2

• RB and DNA damage checkpoint

• P53 easily falls apart, unless DNA damage, then easily stabilized and induce p21

Pathology