# 13 Insulin

## Overview

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Endocrinology/Insulin%20effects%20vary%20by/README.md)..

![](https://f001.backblazeb2.com/file/wikiFiles/MoBJ98N.jpg)

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Endocrinology/Overview%20Insulin%20treatment%20by%20duration%20and%20time%20to%20peak/README.md)..

![](https://f001.backblazeb2.com/file/wikiFiles/POJDU2i.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/oWxPdrr.jpg)

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Endocrinology/Overview%20insulin%20treatment%20by%20method.%20Which%20type%20is%20given%20when?)..

![](https://f001.backblazeb2.com/file/wikiFiles/RnZe5Tl.jpg)

## Rapid acting insulin

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Endocrinology/Insulin%20hexamers%20vs%20monomers/README.md)..

![](https://f001.backblazeb2.com/file/wikiFiles/CPKt1Z1.jpg)

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Endocrinology/Rapid%20acting%20insulin%20examples/README.md)

* Glulisine, aspart, lispro.,
* Girls and lads

![](https://f001.backblazeb2.com/file/wikiFiles/MwuJPtN.jpg)

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Endocrinology/Rapid%20acting%20insulin%20is,%20contains,%20hexamer?,%20duration%20and%20time%20to%20peak,%20given%20when/README.md)

![](https://f001.backblazeb2.com/file/wikiFiles/UR34rPK.jpg)

.,

![](https://f001.backblazeb2.com/file/wikiFiles/oWxPdrr.jpg)

## Regular Insulin

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Endocrinology/Regular%20insulin%20made%20how,%20duration%20and%20time%20to%20peak/README.md)

![](https://f001.backblazeb2.com/file/wikiFiles/Rvnxyqt.jpg)

.,

![](https://f001.backblazeb2.com/file/wikiFiles/oWxPdrr.jpg)

* made with bacteria

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Endocrinology/Regular%20insulin%20used%20when,%20given%20how,%20dosage,%20treats%20what/README.md)

![](https://f001.backblazeb2.com/file/wikiFiles/U1v0mEj.jpg)

.,

* same onset as rapid acting when given IV

## NPH Insulin

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Endocrinology/NPH%20full%20name/README.md)..

![](https://f001.backblazeb2.com/file/wikiFiles/PaHezNt.jpg)

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Endocrinology/NPH%20insulin%20is,%20duration,%20time%20to%20peak/README.md)

![](https://f001.backblazeb2.com/file/wikiFiles/UfxkzPb.jpg)

.,

![](https://f001.backblazeb2.com/file/wikiFiles/oWxPdrr.jpg)

* replaced often by Glargine and Detemir

## Glargine

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Endocrinology/Glargine%20is,%20MOA,%20duration,%20onset,%20given%20how/README.md)

![](https://f001.backblazeb2.com/file/wikiFiles/6dVFM64.jpg)

.,

![](https://f001.backblazeb2.com/file/wikiFiles/oWxPdrr.jpg)

* often given as basal insulin once a day plus bolus rapid action
* form crystals that dissolve slowly once in body

## Detemir

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Endocrinology/Detemir%20is,%20duration,%20onset,%20MOA,%20given%20how,%20SE/README.md)

![](https://f001.backblazeb2.com/file/wikiFiles/wvcTGez.jpg)

.,

![](https://f001.backblazeb2.com/file/wikiFiles/oWxPdrr.jpg)

* absorb slowly once in SQ tissue 
* less weight gain than Glargine

## Insulin Analogs vs insulin molecules

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Endocrinology/Nonhuman%20insulin%20molecules%20vs%20human%20insulin%20molecules/README.md)..

![](https://f001.backblazeb2.com/file/wikiFiles/khLhmO0.jpg)

## SE

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Endocrinology/Insulin%20treatment%20se%20and%20symptoms/README.md)..

* hypoglycemia: tremor, palpitation, anxiety, seizure, coma
* weight gain: from insulin promotin FA/protein synthesis