13 Insulin

Overview

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Rapid acting insulin

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• Glulisine, aspart, lispro.,

• Girls and lads

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Regular Insulin

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• made with bacteria

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• same onset as rapid acting when given IV

NPH Insulin

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• replaced often by Glargine and Detemir

Glargine

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• often given as basal insulin once a day plus bolus rapid action

• form crystals that dissolve slowly once in body

Detemir

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• absorb slowly once in SQ tissue

• less weight gain than Glargine

Insulin Analogs vs insulin molecules

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SE

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• hypoglycemia: tremor, palpitation, anxiety, seizure, coma

• weight gain: from insulin promotin FA/protein synthesis