04 Virus Structure

• glycoproteins for attachments

Capsid

• both made by multiple identical copies of proteins

Envelopes

• icosahedral shape very stable. If not envelope = icosahedral shape

• envelope virus can't survive in environment, not transmitted fecal oral or contaminated water

• Hep B/Herpes/HIV all transmitted directly

RNA

• host cell synthesize proteins using +RNA

• top: + RNA, synthesize directly to proteins

• middle: -RNA, nucleic acid not make sense, can't be translated

• RNA polymerase flip 3' and 5' end and also flip the bases

• no human enzyme available to make RNA from RNA

+RNA

• RNA in cell, immediately translated

• one of translated is RNA polymerase that makes - RNA and also translate - RNA to + RNA genome

-RNA

• positive intermediate RNA translated and made into -RNA genome

Retro

DNA

Infectivity

• whether or not nuclear material can cause infection by themselves

Segmented

• reassorments: pandemics

• papilloma, polyoma, hepadna all have circular DNA