08 HMP Shunt

offshoot of glycolysis
Pathway



not in mitochondria
oxidative: G6P to R5P
reductive: R5P to F6P and G6P
Oxidative

CO2 removed to go from 6C to 5C
Reductive


R5P

NADPH

NADH very different function from NADPH
not used to generate ATP

donate electron to other molecules, reducing them
Phagocytosis


uses NADPH from HMP shunt

Oxidative Damage Protection



glutathione protects RBC from oxidative damage


bite cells: spleen try to remove heinz bodies


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