08 HMP Shunt

  • offshoot of glycolysis

Pathway

  • not in mitochondria

  • oxidative: G6P to R5P

  • reductive: R5P to F6P and G6P

Oxidative

  • CO2 removed to go from 6C to 5C

Reductive

R5P

NADPH

  • NADH very different function from NADPH

  • not used to generate ATP

  • donate electron to other molecules, reducing them

Phagocytosis

  • uses NADPH from HMP shunt

Oxidative Damage Protection

  • glutathione protects RBC from oxidative damage

  • bite cells: spleen try to remove heinz bodies

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