Immunosuppressants

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• autoimmune disease, RA, transplant rejection

Cyclosporine, Tacrolimus

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• calcineurin normally activates NFAT via dephosphorylation

• decreased IL2

• histology: tubule vacuolization

• Diltiazem inhibitor of P450

• usually with phenytoin

Sirolimus

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Methotrexate

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• leucovorin rescue: done in a cycle with methotrexate

Mycophenolic Acid

• B and T cell only

Cyclophosphamide

Azathioprine

• salvages hypoxanthine and guanine to make new nucleotides

• mutant nucleotide, toxic to cells

Muromonab

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• CD3 surface marker, carry signal inside

• initially activate T cells during 1st or second dose

• cytokines flooding from T cells

Infliximab

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• TNF binds Etanercept instead of TNF receptor

Malaria

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• raise pH of lysosomes