Virus Sturcture

Structures

• icosahedral very stable

• enveloped not very stable in environment

• naked: durable protein coat, survive in enviroment

RNA

• host cell synthesize protein for +RNA immediately

• top: positive sense

• middle: negative sense. Nucleic acid not translatable. Must be translated by RNA polymerase, flip 3' and 5' and flip base, strand now looks like +RNA

Replication

• -RNA used to make +RNA genome

• +RNA used to make -RNA genome

DNA

Infectivity

• infectivity: whether or not genetic material can be infectious by itself

Segmented

Overview

• papilloma, polyoma, hepadena: circular DNA

• parvo: smallest, single DNA

• pox: largest, only one replicate in cytoplasm

• corona: helical

Vaccine