18 Nephrotic Syndrome

_..

• may be in casts or in plasma membranes

• mostly LDL not HDL

_..

• diseases damage podocytes leads to nephrotic syndrome

• podocytes walled off from cellular components, no inflammation, no nephritic

_..

Minimal Change Disease

_..

• loss of albumin (-) in urine

• HL: massive production of cytokines

• things trigger cytokines can trigger MCD

• steroids help cytokines

• most other nephrotics not responsive to steroids

• minimal changes on renal biopsy

FSGS

_..

• more serious/dangerous version of MCD

• HIV associated

_..

• IgM, C3

• image: normal upright, abnormal lower left; pink deposition in abnormal

Membranous Nephropathy

_..

• no triggering inflammation

• thick knots in string: Associated with membranous glomerulonephritis

• 3 string: Associated with membranoproliferative glomerulonephritis. Tram track appearance

_..

• if hypercellular: membranoproliferative

• thick GBM

• Spike and Dome

Diabetic Nephropathy

_..

Amyloidosis

_..