02 Pulmonary Physiology
Last updated
Last updated
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TLC: average person, 6 L total
RV: 1 L residual volume
TV: quiet breathing, 2.5 - 3L
Inspiratory Reserve Volume: volume inhaled after inspiration TV
ERV: same with expiration TV
FRC: functional residual capacity, volume left after TV expiration
VC: everything but residual volume
IRV
TV
ERV
RV
bottom 2: FRC
top 2: IC
top 3: VC
all 4: TLC
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not all alveoli exchange gas
apex largest contributor to dead space
ratio of physiologic (not anatomic) deadspace to TV
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lung like a balloon
no pressure: no volume
maximum point: no increase in volume with pressure increase
no pressure: still has a volume
positive pressure increase volume
negative pressure withdraw volume
at 0: no air movement
at FRC: tendency for lungs to collapse balanced by tendency of chest wall to expand, no pressure on air molecules inside alveoli
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by convention, 0 mmHg, no difference between alveoli and atmospheric
at end of expiration/inspiration, no movement of air, pressure equal
exhale: pressure inside becomes positive, drive air out
inhale: pressure inside becomes negative, drive air in
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for pressure in alveoli to be 0 (no airflow), pressure in pleural space must be negative
positive pressure of lung to collapse balanced by negative pressure of pleural space
intrapleural space: always negative during normal breathing
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net sum of pressure differences acting on pleural tissue
pressure +5 pushing in and +5 inside pushing out = 0
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pressure surrounding alveoli become equal to pressure in alveoli
resistance flow slowly drops pressure inside alveoli
beyond equal pressure point: airway collapse prevented by cartilage
bronchitis: +60 closer to alveoli
emphysema: instead of +90, +70 in alveoli
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stiffness of lung
compliant: easy to stretch or move air
infiltrate in lung: stiff (water, fibrosis)
Aging: lung compliance increases (loss of elasticity). Chest wall compliance decreases (rib calcification, stiffening). RV increases (air trapping, like emphysema). FVC decreases (air trapping from increased RV). TLC stays same (decreased chest wall compliance balances lung compliance).
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very slow laminar flow good for O2 transmission