> For the complete documentation index, see [llms.txt](https://thisispiggy.gitbook.io/my-wiki/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://thisispiggy.gitbook.io/my-wiki/01-step-1/immunology/05-spleen.md).

# 05 Spleen

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Immunology/what%20is%20lymph,%20drains%20where/README.md)..

![](https://i.imgur.com/nOfdPV2.jpg)

## Lymphoid Organs

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Immunology/primary%20vs%20secondary%20lymph%20organs%20and%20function/README.md)..

![](https://i.imgur.com/0Uf1FFg.jpg)

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Immunology/Lymph%20node%20components.%203%20layers.%20Where%20does%20lymph%20go%20in%20and%20out)..

![](https://i.imgur.com/wyg4YrY.jpg)

* Cortex: white, contains **follicle**
* Paracortex: T cells
* Medulla with cords and sinus
* Afferent lymph goes through the 3 layers, exit at 1 efferent vessel

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Immunology/lymph%20node%20function.%20How%20does%20it%20happen.%20End%20result)..

![](https://i.imgur.com/USd5vKr.jpg)

* APC process free antigens

### Cortex

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Immunology/what%20and%20where%20are%20lymphoid%20follicles.%20Function,%20contains%20what%20cells.%20Why%20are%20they%20important%20in%20HIV)..

![](https://i.imgur.com/7Fsdf40.jpg)

* dendritic cell like velcro picking up antigens that allow B cell to react

![](https://i.imgur.com/wyg4YrY.jpg)

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Immunology/primary%20vs%20secondary%20lymphoid%20follicles/README.md)..

![](https://i.imgur.com/kR1vIch.jpg)

![](https://i.imgur.com/gjxUW1j.jpg)

* 4: follicle
* 3: white, germinal center, thus secondary follicle

### Paracortex

\[\_]\(Paracortex contains what cells. Classic disorder. How does it respond during infection. What's so special about the venules)..

![](https://i.imgur.com/Bxe3Pti.jpg)

![](https://i.imgur.com/iriPCpv.jpg)

* HEV: spaces between endothelium to allow B and T from blood to enter lymph

![](https://i.imgur.com/wyg4YrY.jpg)

### Medulla

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Immunology/2%20parts%20of%20the%20medulla,%20contains%20what%20cells,%20function.)..

![](https://i.imgur.com/ZktKP9Q.jpg)

![](https://i.imgur.com/wyg4YrY.jpg)

## Spleen

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Immunology/spleen%20function,%20does%20not%20do%20what/README.md)..

![](https://i.imgur.com/Msib0GJ.jpg)

* not lymph filter
* filters blood
* everything in blood enters spleen

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Immunology/Spleen%20components,%20functions%20in%20each/README.md)..

![](https://i.imgur.com/YVAvrsf.jpg)

* first from artery to white pulp (white)
* then blood moves through red section, red pulp
* eventually back to splenic vein

![](https://i.imgur.com/8KV7MPC.jpg)

### White Pulp

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Immunology/white%20pulp%20components.%20Cells%20in%20each)..

![](https://i.imgur.com/pkh2IEe.jpg)

![](https://i.imgur.com/YVAvrsf.jpg)

### Red Pulp

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Immunology/red%20pulp%20contains,%20cells/README.md)..

![](https://i.imgur.com/q6r1nCV.jpg)

![](https://i.imgur.com/nSFaYUX.jpg)

* endothelium with barrel hoop membrane. Still large enough for blood to pass through

![](https://i.imgur.com/YVAvrsf.jpg)

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Immunology/Splenic%20dysfunction%20infection%20risk.%20MOA)..

![](https://i.imgur.com/Q1PKHLb.jpg)

* less complement activity because needs IgG and IgM for binding Fc

![](https://i.imgur.com/TufFaYk.jpg)

* antibody binding leads to MAC and c3b formation
* macrophage binds to antibody and c3b, phagocytosis

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Immunology/common%20splenic%20dysfunction%20organisms/README.md)..

![](https://i.imgur.com/1sMAJ3S.jpg)

* malaria/babesia: infected RBC can't be cleared

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Immunology/splenic%20dysfunction%20cause/README.md)..

![](https://i.imgur.com/LME2B1s.jpg)

* ITP: low platelets. Take out spleen to increase platelet
* spherocytosis: take spleen out, less destruction of anemia
* Sickle cell: so many abnormal RBC that damages spleen when removed 

[\_](https://github.com/thisispiggy/my-wiki/tree/601ff771dc2fac1318ae8b59435ac8485628fd81/01%20Step%201/Immunology/splenic%20dysfunction%20histology%20RBCs/README.md)..

![](https://i.imgur.com/bEi7kAC.jpg)

* target cells usually cleared by spleen

![](https://i.imgur.com/y80yiqx.jpg)