03 Hypercoagulable States
Last updated
Last updated
inflammation: ongoing clot formation
DVT/PE common
also antiphosphilid syndrome
make excess prothrombin
given high dose of heparin but no change in PTT
arterial thrombosis uncommon
3 anti-phospholipid antibodies
RPR antigen bound by syphillis antibodies, but also can be bound by anti-cardiolipin antibodies
intrinsic cascade requires phospholipids. In body on cell membrane. In lab added extrinsically. Lupus anticoagulant will inactivate phospholipids added = false prolongation of PTT
contact factor activates 12
people have antibodies but not syndrome
clotting factors: blue circles
lupus anticoagulant: triangles
mixing study: still prolonged PTT
hemophilia: clotting factor deficiency
unprovoked: didn't occur after plane flight/surgery