# 06 Imprinting

![](https://f001.backblazeb2.com/file/wikiFiles/96A5B1B6-ACD3-405D-9DCA-AA0365DF04D6.jpg)

* gene expression not structure
* different expression depending on whether from mother or father

![](https://f001.backblazeb2.com/file/wikiFiles/0F168386-0E23-4AF8-B6FD-D359B1C6D020.jpg)

* normally both copies expressed
* imprinting: one of the copy not expressed

![](https://f001.backblazeb2.com/file/wikiFiles/83D3EBCE-B4D5-45D5-9345-104CF9F368D9.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/26EEEC3D-AA64-486B-99B5-B6DAFEA4C3F4.jpg)

## Pathology

![](https://f001.backblazeb2.com/file/wikiFiles/FC2972EB-4259-403C-8B95-00061D719DD3.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/77930BB5-E7B6-4D6B-B99B-20C6545D3A62.jpg)

### Prader-Willi

![](https://f001.backblazeb2.com/file/wikiFiles/68D7EEE2-69D0-4051-BFE7-B2D7E69B9770.jpg)

* P for paternal and prader
* maternal normally not expressed
* loos of paternal = no functioning gene

![](https://f001.backblazeb2.com/file/wikiFiles/F4C3E243-7C81-4F5A-B7E7-708867C57C09.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/92A8F29D-1455-4FB9-8735-21905D9C8A02.jpg)

* angelman severe intellectual

### Angelman

![](https://f001.backblazeb2.com/file/wikiFiles/5A1EF32D-EB01-4106-BD70-5CB243DB501A.jpg)

![](https://f001.backblazeb2.com/file/wikiFiles/FBB2DB22-6779-4EA3-B6CF-914CCF5DAEF4.jpg)

* meiotic nondisjunction rarer in males

![](https://f001.backblazeb2.com/file/wikiFiles/030C640D-77B0-469B-8BAB-DCDD8A7A7E94.jpg)
